According to 1up.com,

Payton knows fans have legitimate concerns about Kojima Productions possibly compromising the game’s ambition due to issues arising from concurrent Xbox 360 development — divided resources, less disc space, etc. — and he addressed those directly:

“I can tell you honestly at this point, we have not changed the game in any form with the idea of ‘oh, we got to do this on 360.’ Put aside whether or not we’re developing for 360 or not, the game is built on the PS3 hardware, as you guys have known for the past two years or so.”

In other words: if MGS4 comes to Xbox 360, it has not affected the game’s development. This is the same game Hideo Kojima decided to produce from day one. Make sure to listen to the podcast for more from Payton and the 1UP boys about Snake, Xbox 360 vs. PS3 and more.
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