According to Scrawlfx.com, "the latest issue of  Portugal’s PlayStation: The Official Magazine is teasing the reveal of inFAMOUS 2 in their next issue."  While this isn't confirmed, it's certainly likely given the picture appearing at the end of the magazine(check it out on the bottom of the article).

Like Sal at Scrawlfx.com, I share his concern that E3 may become over-saturated with sequels. Sony looks to have an overwhelming amount of titles in development.